Resolution of (+/-)-mandelic- and (+/-)-2-(chlorophenoxy)propionic-acid derivatives by crystallization of their diastereomeric amides with (R)- or (S)-alpha-arylethylamines

Authors
Jourdain, F Hirokawa, T Kogane, T
Citation
F. Jourdain et al., Resolution of (+/-)-mandelic- and (+/-)-2-(chlorophenoxy)propionic-acid derivatives by crystallization of their diastereomeric amides with (R)- or (S)-alpha-arylethylamines, TETRAHEDR L, 40(13), 1999, pp. 2509-2512
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
13
Year of publication
1999
Pages
2509 - 2512
Database
ISI
SICI code
0040-4039(19990326)40:13<2509:RO(A(D>2.0.ZU;2-O
Abstract
An alternative and cost effective route for the resolution in high ees (95- 99%) of (+/-)-mandelic and (+/-)-2-(chlorophenoxy)propionic- acid derivativ es is reported. The key step involves the covalent derivatization and separ ation of their diastereomeric amides with (R)- or (S)-alpha-arylethylamines . (C) 1999 Elsevier Science Ltd. All rights reserved.