Synthesis of imifuramine and its stereoisomers exhibiting histamine H-3 agonistic activity

Authors
Harusawa, S Imazu, T Takashima, S Araki, L Ohishi, H Kurihara, T Yamamoto, Y Yamatodani, A
Citation
S. Harusawa et al., Synthesis of imifuramine and its stereoisomers exhibiting histamine H-3 agonistic activity, TETRAHEDR L, 40(13), 1999, pp. 2561-2564
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
13
Year of publication
1999
Pages
2561 - 2564
Database
ISI
SICI code
0040-4039(19990326)40:13<2561:SOIAIS>2.0.ZU;2-4
Abstract
The four possible stereoisomers of a novel imidazole C-nucleoside derivativ e were synthesized by the efficient use of a PhSe group. Among them, (+)-4( 5)-[(2R,5R)-5-(aminomethyl)tetrahydrofuran-2-yl]imidazole (imifuramine) was indicated as a novel type of histamine H-3-agonist by a brain microdialysi s method. (C) 1999 Elsevier Science Ltd. All rights reserved.