Catalytic asymmetric addition of diphenylphosphine oxide to cyclic imines

Authors
Yamakoshi, K Harwood, SJ Kanai, M Shibasaki, M
Citation
K. Yamakoshi et al., Catalytic asymmetric addition of diphenylphosphine oxide to cyclic imines, TETRAHEDR L, 40(13), 1999, pp. 2565-2568
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
13
Year of publication
1999
Pages
2565 - 2568
Database
ISI
SICI code
0040-4039(19990326)40:13<2565:CAAODO>2.0.ZU;2-4
Abstract
The catalytic asymmetric addition of diphenylphosphine oxide to cyclic it-n ines is reported for the first time. The addition, catalyzed by a heterobim etallic lanthanoid complex, gives the corresponding amino phosphine oxide p roducts in good to excellent yields and up to 93% ee. The preliminary resul t of the application of one of these products as a chiral ligand is also de scribed. (C) 1999 Elsevier Science Ltd. All rights reserved.