Efficient total synthesis of pentosidine, an advanced glycation endproduct

Authors
Sugiyama, H Yokokawa, F Shioiri, T Katagiri, N Oda, O Ogawa, H
Citation
H. Sugiyama et al., Efficient total synthesis of pentosidine, an advanced glycation endproduct, TETRAHEDR L, 40(13), 1999, pp. 2569-2572
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
13
Year of publication
1999
Pages
2569 - 2572
Database
ISI
SICI code
0040-4039(19990326)40:13<2569:ETSOPA>2.0.ZU;2-R
Abstract
The efficient total synthesis of pentosidine (1), an advanced glycation end product, was achieved using the asymmetric alkylation of a chiral schiff ba se (2), the intramolecular guanylation with mercury (II) chloride, and the quaternization accompanied by removal of the trityl group as key steps. (C) 1999 Elsevier Science Ltd. All rights reserved.