Synthesis of the phosphodisaccharide repeat of antigenic lipophosphoglycanof Leishmania donovani parasite

Authors
Upreti, M Vishwakarma, RA
Citation
M. Upreti et Ra. Vishwakarma, Synthesis of the phosphodisaccharide repeat of antigenic lipophosphoglycanof Leishmania donovani parasite, TETRAHEDR L, 40(13), 1999, pp. 2619-2622
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
13
Year of publication
1999
Pages
2619 - 2622
Database
ISI
SICI code
0040-4039(19990326)40:13<2619:SOTPRO>2.0.ZU;2-V
Abstract
Synthesis of the immunologically important and structurally unusual phospho disaccharide repeat unit (Galp1,4 beta-Manp-1 alpha-phosphate) of the lipop hosphoglycan cell surface GPI molecule of the protozoan parasite Leishmania donovani has been carried out using lactose as the starting material. The synthesis provides a short and stereoselective route for the preparation of this phosphosaccharide in a preparative scale. (C) 1999 Published by Elsev ier Science Ltd. All rights reserved.