INHIBITION BY 2-ARACHIDONOYLGLYCEROL, A NOVEL TYPE OF POSSIBLE NEUROMODULATOR, OF THE DEPOLARIZATION-INDUCED INCREASE IN INTRACELLULAR FREECALCIUM IN NEUROBLASTOMA X GLIOMA HYBRID NG108-15 CELLS
T. Sugiura et al., INHIBITION BY 2-ARACHIDONOYLGLYCEROL, A NOVEL TYPE OF POSSIBLE NEUROMODULATOR, OF THE DEPOLARIZATION-INDUCED INCREASE IN INTRACELLULAR FREECALCIUM IN NEUROBLASTOMA X GLIOMA HYBRID NG108-15 CELLS, Biochemical and biophysical research communications, 233(1), 1997, pp. 207-210
2-Arachidonoylglycerol was found to inhibit the depolarization-induced
increase in [Ca2+](i) in NG108-15 cells differentiated with prostagla
ndin E-1 and theophylline in a dose-dependent manner. Such an effect a
ppears to be rather specific to polyunsaturated fatty acid-containing
monoacylglycerols such as 2-arachidonoylglycerol. Neither 2-palmitoylg
lycerol nor free arachidonic acid exhibited appreciable inhibitory act
ivity. These observations raise the possibility that 2-arachidonoylgly
cerol attenuates the increase in [Ca2+](i), thereby modulating several
neural functions in this type of cell. (C) 1997 Academic Press.