The tridimensional personality questionnaire as a predictor of relapse in detoxified alcohol dependents

Personality traits have been found as strong predictors for treatment respo nse in different psychiatric disorders. We administered the Tridimensional Personality Questionnaire, which measures the three personality dimensions: novelty seeking, harm avoidance (HA), and reward dependence, as introduced by Cloninger in a multicenter study (11 centers in the United Kingdom, fir e, Switzerland, and Austria) with detoxified alcohol-dependent patients (n = 521). The objective of this study was to evaluate a possible predictive v alue of these three dimensions on relapse over 1-year follow up. A logistic regression analysis showed that novelty seeking is a strong predictor for relapse in detoxified male alcoholics (p = 0.0007; p values adjusted for tr eatment), but not in females. In both sexes, HA and reward dependence were of no predictive value. However, we found a trend for significance of HA fo r predicting "early" relapse (4 weeks) in females (p = 0.074). Our results show that Tridimensional Personality Questionnaire personality traits have direct clinical applications for prediction of relapse in detoxified alcoho l dependents and indicate the necessity of additional therapeutic treatment in risk groups.