Economic analysis of a randomized placebo-controlled phase III study of granulocyte macrophage colony stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia

Purpose: Considerable morbidity and mortality and costs occur during induct ion therapy for acute myeloid leukemia (AML). Colony-stimulating factors (C SFs) can shorten neutropenia, and may lower costs. We performed a cost-mini mization analysis of granulocyte macrophage colony stimulating factor (GM-C SF) for AML patients > 55 to 70 years of age during an Eastern Cooperative Oncology Group Study. Patients and methods: Clinical data were from a randomized double-blind pha se III trial of 117 AML patients. Estimates of costs were from financial ac counts from seven participating institutions. Costs were reported from the third party payor perspective. Analyses were conducted utilizing a decision analytic model. The primary source of event probabilities was in-hospital care with or without an active infection. Sensitivity analyses were also re ported. Results: When compared to AML patients who received placebo, GM-CSF patient s had fewer grade 4-5 infections (9.6% versus 36.2%, P = 0.002) and grade 3 -5 infections (52% versus 70%, P = 0.07) and $2,310 in savings. Sensitivity analy ses indicated that similar cost estimates applied over a range of cl inical and economic assumptions. Conclusions: This analysis can serve as a template for cooperative group co st analyses. Cooperation on study methodologies may allow for results that are relevant to both clinicians and policy makers.