Effect of carbohydrate intake on serum 3,5,3 '-triiodothyronine-response to glucose ingestion and its relation to glucose tolerance in lean non-insulin-dependent diabetic patients

This study was conducted to know the effect of carbohydrate intake on serum 3,5,3'-triiodothyronine (CAS 6893-02-3, T-3) -response to glucose ingestio n and its relation to glucose tolerance in lean non-insulin-dependent diabe tes mellitus (NIDDM) patients. Ten patients, body mass index: 21.8 +/- 2.2 (mean +/- SD) kg/m(2), were given a control diet (2012 kcal/day(d); carbohy drate (CHO): 299 g/d) on admission. Several days later, they were given a l ow-calory and low-CHO diet (Low-CHO) (1156 kcal/d: CHO: 139 g/d) and 2 week s later, they received a low-calory rind high-CHO diet (High-CHO) (1154 kca l/d; CHO: 176 g/d) and another 2 weeks later, they were given Low-CHO again for 2 weeks. They received oral 75 g glucose tolerance tests after complet ion of each diet. Sigma dGlucose (mmol/l) decreased from 54.3 +/-. 11.9 (co ntrol) to 42.5 +/- 7.5 after Low-CHO and reached 34.5 +/- 10.4 after High-C HO but increased to 36.4 +/- 11.1 after the 2nd Low-CHO (F = 7.46, p = 0.00 05). Sigma dT(3) (nmol/l) increased from -0.18 +/- 0.52 (control) to 0.12 /- 0.67 after Low-CHO and reached 0.92 +/- 0.59 after High-CHO but decrease d to 0.36 +/- 0.65 after the 2nd Low-CHO (F = 5.92, p = 0.0022. Serum insul in and body weight remained unchanged throughout the study. Negative correl ation between Sigma dT(3) and Sigma dGlucose (r = -0.493, n = 40, p = 0.001 2) was found throughout the diet modification. Carbohydrate intake affected serum T-3-response to glucose ingestion and the response was closely relat ed to glucose tolerance in lean NIDDM patients.