Conversion of chylomicrons into remnants

The turnover of chylomicrons in the blood is the sum of several processes. The native chylomicron is synthezised in the intestine out of available sub strates. When the chylomicron enters the circulation exchanges of apolipopr oteins with other lipoproteins, it also binds to the vascular endothelium w here the chylomicron is lipolyzed by lipoprotein lipase. After a short peri od in the circulation the chylomicron/chylomicron remnant appears to be ava ilable for receptor mediated uptake. In this paper several of the processes involved in generation and clearance of chylomicron remnants are discussed . (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.