Effect of dietary supplementation with zinc sulphate on the aging process:a study using high field intensity MRI and chemical shift imaging

High field intensity magnetic resonance imaging (HF-MRI) has been applied t o the in vivo study of age-related processes of organs located in the cervi cal-thoracic region in mice and to describe the effects of oral zinc supple mentation on these processes. Spin-echo (SE) pulse sequence and chemical sh ift imaging (CSI) techniques have been used. Aging produced a progressive r eduction of muscular masses and of thymic area, whereas the HF-MRI appearan ces of spinal cord and of salivary glands were unchanged. In some aged anim als, subcutaneous fat was reduced while visceral fat was well developed. In the group of old animals supplemented with zinc sulphate, muscular masses were more developed than that of the group of untreated old animals. Oral z inc supplementation also produced an enlargement of the adipose tissue and the thymic area showed an increase of about 65 % compared with thymic area measured in the group of old animals used as controls. The present study co nfirms previous data about the effects of Zn supplementation on aging proce sses and demonstrates that HF-MRI is a powerful technique to study processe s of aging, providing information about the effects of drug treatments on t hese processes. (C) 1998 Elsevier, Paris.