Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice

Body temperature changes and heat shock protein (HSP-72) induction in the c audate nucleus were studied in female C57BL/6N mice pretreated with ibogain e (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (2 0 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HS P-72 expression, whereas treatment with ibogaine alone produced hypothermia . The ibogaine followed by methamphetamine injection showed no hyperthermia and decreased HSP-72 expression. These data indicate that pretreatment wit h ibogaine can completely block methamphetamine-induced hyperthermia and HS P-72 expression in the striatum. (C) 1999 Elsevier Science B.V. All rights reserved.