A male member of a large HNPCC kindred, affected by primary malignancies of
the breast and colon, was identified. This individual was found to harbor
a germline mutation of the MLH1 mismatch repair gene previously shown to se
gregate with disease in this kindred. The breast tumor exhibited somatic re
duction to homozygosity for the MLH1 mutation, and microsatellite instabili
ty was evident in the breast tumor. We conclude that hereditary male breast
cancer can occur as an integral tumor in the HNPCC syndrome.