H. Avet-loiseau et al., Comparative genome hybridization detects many recurrent imbalances in central nervous system primitive neuroectodermal tumours in children, BR J CANC, 79(11-12), 1999, pp. 1843-1847
A series of 23 children with primitive neuroectodermal tumours (PNET) were
analysed with comparative genomic hybridization (CGH). Multiple chromosomal
imbalances have been detected in 20 patients. The most frequently involved
chromosome was chromosome 17, with a gain of 17q (11 cases) and loss of 17
p (eight cases). Further recurrent copy number changes were detected. Extra
copies of chromosome 7 were present in nine patients and gains of Iq were
detected in six patients. A moderate genomic amplification was detected in
one patient, involving two sites on 3p and the whole 12p. Losses were more
frequent, and especially involved the chromosomes 11 (nine cases), 10q (eig
ht cases), 8 (six cases), X (six patients) and 3 (five cases), and part of
chromosome 9 (five cases). These recurrent chromosomal changes may highligh
t locations of novel genes with an important role in the development and/or
progression of PNET.