Although hepatobiliary involvement is common in the acquired immunodef
iciency syndrome, it infrequently leads to biliary tract abnormalities
. We describe a 39-year-old man with human immunodeficiency virus infe
ction and no previous acquired immunodeficiency syndrome-defining illn
esses, who presented with malaise, right upper quadrant pain, lymphade
nopathy and cholestasis. An endoscopic retrograde cholangiopancreatogr
aphy demonstrated sclerosing cholangitis due to disseminated B-cell no
n-Hodgkin's lymphoma. Following chemotherapy, his symptoms and signs r
apidly improved, so that 1 month later his endoscopic retrograde chola
ngiopancreatography had returned entirely to normal.