Je. Cortes et al., A pilot study of interleukin-2 for adult patients with acute myelogenous leukemia in first complete remission, CANCER, 85(7), 1999, pp. 1506-1513
BACKGROUND. Interleukin-2 (IL-2) has immunomodulatory effects, including st
imulating the activity of cytotoxic T cells and natural killer cells, and i
nducing the generation of lymphokine-activated killer cells. The authors in
vestigated whether IL-2 may improve the duration of complete remission (CR)
and survival in acute myelogenous leukemia (AML) patients in first CR.
METHODS. Eighteen patients were included after achieving a CR and receiving
at least two courses of consolidation chemotherapy. Therapy was comprised
of IL-2 4.5 x 10(5) U/m(2) daily by continuous infusion (CI) for 12 weeks,
plus boluses of 1 x 10(6) U/m(2) on Day 8 and weekly thereafter while conti
nuing the CI. No further chemotherapy was given after the administration of
IL-2 was started.
RESULTS. The median age of the patients was 50 years (range, 18-73 years),
and 7 patients (39%) had an antecedent hematologic disorder (AHD). The medi
an CR duration was 12 months, with 6 patients still alive in CR at a median
follow-up of 64 months (range, 50-82 months). Long term CR by cytogenetics
occurred in 2 of 5 patients with a normal karyotype (CR duration of 68+ mo
nths and 72+ months, respectively), 1 of 3 patients with t(8;21) (CR durati
on of 82+ months), 1 patient with inv(16) (CR duration of 67+ months), none
of 2 patients with -5/-7 (1 patient died in CR after 10 months), 1 of 2 pa
tients with abnormalities in chromosome 11 (CR duration of 60+ months), and
1 of 4 patients with miscellaneous abnormalities (CR duration of 74+ month
s). The median survival was 47 months. To assess the significance of these
results, the authors selected two historic controls receiving long term pos
tremission chemotherapy per each IL-2 case. The controls had remained in CR
for at least as long as the cases when the latter underwent treatment init
iation with IL-2 and were matched for the number of induction courses requi
red to achieve CR, AHD, cytogenetic abnormalities, and age. Six of 18 IL-2
patients (33%) were alive in CR at 3 years compared with 7 of 36 controls (
19%) (P = 0.31). Nine IL-2 patients (50%) were alive at 3 years compared wi
th 10 controls (28%) (P = 0.13).
CONCLUSIONS. These results suggest that IL-2 is tolerable in AML patients i
n first CR and should be studied further in future studies as a therapeutic
strategy to prolong remission duration. (C) 1999 American Cancer Society.