Genotoxic potential of cyclosporin A in patients with renal transplantation

Authors
Palanduz, S Sever, MS Ozturk, S Tascioglu, C Karan, MA Sonmez, G Cefle, K Guler, K
Citation
S. Palanduz et al., Genotoxic potential of cyclosporin A in patients with renal transplantation, CELL BIOL T, 15(1), 1999, pp. 13-17
Citations number
26
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL BIOLOGY AND TOXICOLOGY
ISSN journal
07422091 → ACNP
Volume
15
Issue
1
Year of publication
1999
Pages
13 - 17
Database
ISI
SICI code
0742-2091(199902)15:1<13:GPOCAI>2.0.ZU;2-Y
Abstract
We analyzed the induction of sister chromatid exchange (SCE) by cyclosporin A (CsA) as a marker of genotoxic potential. In 30 patients undergoing rena l transplantation, SCE induction was tested before the introduction of CsA and 3 months later. We found that SCE frequency increased significantly at the end of 3 months. To our knowledge, this is the first study demonstratin g in viva induction of SCE by CsA in humans. We conclude that CsA has a gen otoxic potential on human lymphocytes.