MOLECULAR MECHANISMS OF AZOLE RESISTANCE IN FUNGI

Citation
T. Josephhorne et Dw. Hollomon, MOLECULAR MECHANISMS OF AZOLE RESISTANCE IN FUNGI, FEMS microbiology letters, 149(2), 1997, pp. 141-149
Citations number
33
Categorie Soggetti
Microbiology
Journal title
ISSN journal
03781097
Volume
149
Issue
2
Year of publication
1997
Pages
141 - 149
Database
ISI
SICI code
0378-1097(1997)149:2<141:MMOARI>2.0.ZU;2-U
Abstract
This paper reviews the current status of our understanding of azole an tifungal resistance mechanisms at the molecular level and explores the ir implications. Extensive biochemical studies have highlighted a sign ificant diversity in mechanisms conferring resistance to azoles, which include alterations in sterol biosynthesis, target site, uptake and e fflux. In stark contrast, few examples document the molecular basis of azole resistance. Those that do refer almost exclusively to mechanism s in laboratory mutants, with the exception of the role of multi-drug resistance proteins in clinical isolates of Candida albicans. It is cl ear that the technologies required to examine and define azole resista nce mechanisms at the molecular level exist, but research appears dist inctly lacking in this most important area.