In horses, the ingestion of wilted or dried red maple leaves can result in
fatal hemolytic anemia. The toxic principle in red maple leaves is unknown
but is believed to be an oxidant The most common clinical signs are the pas
sage of reddish-brown urine and brown discoloration of the blood and mucous
membranes. Laboratory abnormalities usually include methemoglobinemia and
the presence of Heinz bodies and eccentrocytes. Diagnosis is based on a his
tory of exposure to red maple leaves and eliminating other possible causes
of hemolytic anemia. Treatment centers around supportive care and may inclu
de blood transfusions.