Ovary non seminomatous malignant germ cell tumours

Ovary seminomatous malignant germ cell tumours are a particular histopathol ogica entity. The presence of yolk salk tumor or choriocarcinoma is respect ively correlated with elevation of alpha FP or beta hCG, This markers eleva tion permits to assess diagnosis, appreciate response to treatment, and det ect relapses, The study of 64 patients registered in two successive S.F.O.P . protocols (TGM 85-TGM 90) precise indications of surgery, platin-based ch emotherapy and results. Malignant non seminomatous germ cell tumors are sep arated in not secreting pure immature teratoma and secreting malignant germ cell tumours. Surgery is essential for treatment of not secreting pure imm ature teratoma, Secreting germ cell tumors are very chemosensitive and surg ery must be as conservative as possible in all cases even metastatic tumour or relapse. If markers are normalized second-look surgery of secreting mal ignant germ cell tumours is only necessary in case of evident residual tumo ur However in case of initial chemotherapy: resection of a pathological ova ry is always performed at the end of treatment. These tumours have a good p rognosis : 5-years overall survival and disease-free survival are 85 %.