Tumor necrosis factor during pregnancy and at the onset of labor and spontaneous abortion

Objective: The aim of this study was to evaluate the production of tumor ne crosis factor (TNF) by peripheral blood cells during pregnancy, at the onse t of labor and of spontaneous abortion (SA), as well as in non-pregnant wom en with and without a history of recurrent spontaneous abortions (RSA). Stu dy design: The peripheral blood cells TNF production was evaluated in 28 wo men in the Ist trimester of pregnancy, 21 in the 2nd, and 30 in the 3rd, 47 at term labor; 43, at the onset of SA; 19 healthy and 19 RSA non-pregnant women. The statistical method used was the Mann-Whitney test. Results: We o bserved (1) lack of TNF detection in the Ist gestational trimester; (2) inc rease of TNF production with gestational age, with the highest values being observed at labor (P<0.05); (3) high TNF production at the onset of SA; (4 ) no difference in the TNF production by healthy and RSA non-pregnant women . Conclusions: The suppression of TNF production during the Ist trimester o f pregnancy seems to favor the normal development of pregnancy. It remains to be investigated whether the assessment of TNF production is a valuable p rognostic parameter for the occurrence of abortion. (C) 1999 Elsevier Scien ce Ireland Ltd. All rights reserved.