Pregnancy in Gaucher disease

An Ig-year old woman with type I Gaucher disease and two uncomplicated preg nancies is described. Although she experienced one miscarriage and pregnanc y was associated with exaggeration of the clinical symptoms, leading to the diagnosis of the disorder, both her 2nd and 3rd pregnancies were uneventfu l and deterioration of her clinical situation was not observed. The issue o f criteria for risk assessment in pregnancy of type I Gaucher disease patie nts is addressed. (C) 1999 Elsevier Science Ireland Ltd. All rights reserve d.