Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2

We report here the identification of a human genomic sequence from the q27. 2 region of the X chromosome which shows a high homology to the L-MYC proto -oncogene. This sequence is not the MYCL2 homology, previously mapped to th e long arm of the X chromosome at q22-qter by Morton et al,, as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, betwee n the DXS312 and DXS292 loci. (C) 1999 Federation of European Biochemical S ocieties.