A. Nasseri et al., Elevated day 3 serum follicle stimulating hormone and/or estradiol may predict fetal aneuploidy, FERT STERIL, 71(4), 1999, pp. 715-718
Objective: To determine whether baseline serum FSH and/or E-2 concentration
s can predict the risk for fetal chromosomal abnormalities.
Design: Case control study.
Setting: Reproductive technology program at a university hospital.
Patient(s): Patients who underwent dilation and curettage (D + C), and whos
e products of conception were karyotyped.
Intervention(s): Patients underwent natural conception or controlled ovaria
n hyperstimulation followed by intrauterine insemination, in vitro fertiliz
ation and embryo transfer, gamete intrafallopian transfer, or zygote intraf
allopian transfer.
Main Outcome Measure(s): Baseline serum FSH and E-2 concentrations and feta
l karyotype.
Result(s): Genetic evaluation of 78 D + C specimens revealed 34 normal and
34 abnormal fetal karyotypes. A significantly greater proportion of women w
ith abnormal fetal karyotype had elevated baseline serum FSH (greater than
or equal to 15 mIU/mL [RIA] or 10 mIU/mL [Immulite]) and/or E-2 (greater th
an or equal to 50 pg/mL [Immulite]) compared with women of normal fetal kar
yotype. Among karyotypically abnormal abortuses, autosomal trisomy was the
most common abnormality noted (79.5%), followed by mosaicism (6.8%), triplo
idy (6.8%), monosomy XO (4.5%), and balanced translocation (2.3%).
Conclusion(s): Baseline serum FSH and/or E-2 concentrations may be valuable
as predictors of fetal aneuploidy. (C) 1999 by American Society for Reprod
uctive Medicine.