More than thirty types of tumors in the sellar region can mimic pituit
ary adenoma on, magnetic resonance imaging. When they exist, clinical
manifestations are not necessarily highly contributive to diagnosis. H
eadache, visual impairment, signs of antepituitary insufficiency or po
ssible dysmenorrhea with galactorrhea attributed to hyperprolactinemia
due to compression of the dopaminergic axis are not specific and may
be misleading. Clinical signs of diabetes insipidis and polyphagia are
however suggestive of non-pituitary tumors. Consequently, high-resolu
tion imaging (MRI) and sometimes particular diagnostic circumstances (
post partum for hypophysitis for example, or breast cancer for metasta
sis) orient the diagnosis. More rarely tumor enlargement, for example
in certain germ cell tumors, provides a clue.