Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray

The development of cancer is the result of a series of molecular changes oc curring in the cell. These events lead to changes in the expression level o f numerous genes that result in different phenotypic characteristics of tum ors. In this report we describe the assembly and utilization of a 5766 memb er cDNA microarray to study the differences in gene expression between norm al and neoplastic human ovarian tissues. Several genes that may have biolog ical relevance in the process of ovarian carcinogenesis have been identifie d through this approach. Analyzing the results of microarray hybridizations may provides new leads for tumor diagnosis and intervention. (C) 1999 Else vier Science B.V. All rights reserved.