Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis

Neurodevelopmental outcomes of human immunodeficiency virus Type 1 (HIV-1)- infected infants of non-drug-using mothers were assessed in a controlled, p rospective study from birth to 24 months with 3 groups: 61 infants of HIV-i nfected mothers, 234 uninfected infants of HIV-infected mothers (serorevert ers), and 115 uninfected infants of uninfected mothers. Compared with seror everters and uninfected infants, HIV-infected infants demonstrated lower me ntal and motor development on the Bayley Scales and greater deceleration in their rate of motor development. HIV-infected infants with abnormal neurol ogic exams had lower motor and mental test scores and lower rates of motor Bayley Scales scores than their HIV-infected counterparts with normal neuro logic exams. Contrary to prediction, no group differences in mean performan ce or growth rates were found on visual information processing on the Fagan Test of Infant Intelligence.