Contribution of interleukin 1 beta and KM loci to alopecia areata

Authors
Galbraith, GMP Palesch, Y Gore, EA Pandey, JP
Citation
Gmp. Galbraith et al., Contribution of interleukin 1 beta and KM loci to alopecia areata, HUMAN HERED, 49(2), 1999, pp. 85-89
Citations number
31
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN HEREDITY
ISSN journal
00015652 → ACNP
Volume
49
Issue
2
Year of publication
1999
Pages
85 - 89
Database
ISI
SICI code
0001-5652(1999)49:2<85:COI1BA>2.0.ZU;2-R
Abstract
Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1 beta may play a pathogenic role. In this study, we examined t he distribution of genotypes of an IL-1 beta single base change polymorphis m at position +3953 in patients with alopecia areata, The distribution of i mmunoglobulin kappa light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1 beta and KM loci act cooperatively to si gnificantly increase susceptibility to alopecia areata.