No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia

Authors
Kouzmenko, AP Scaffidi, A Pereira, AM Hayes, WL Copolov, DL Dean, B
Citation
Ap. Kouzmenko et al., No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia, HUMAN HERED, 49(2), 1999, pp. 103-105
Citations number
16
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN HEREDITY
ISSN journal
00015652 → ACNP
Volume
49
Issue
2
Year of publication
1999
Pages
103 - 105
Database
ISI
SICI code
0001-5652(1999)49:2<103:NCBAPI>2.0.ZU;2-D
Abstract
The A(-1438)G promoter polymorphism of the 5-hydroxytryptamine 2a receptor (5-HT2AR) gene and its influence on the cortical density of 5-HT2AR was stu died using brain tissue donated at autopsy from 58 schizophrenic and 64 non -schizophrenic subjects. A linkage between genotypes for the A(-1438)G and a T102C polymorphic site identified in a previous study was observed. Our d ata suggest no association of the A(-1438)G polymorphism with schizophrenia and no effect of the promoter genotype upon 5-HT2AR densities in either th e schizophrenic or non-schizophrenic groups.