Sixty-five patients with the fourth stage colon cancer were subjected to th
e combined surgical and immunotherapy. The following conclusions are made:
(1) surgical elimination of the bulk of tumor mass is a necessary prerequis
ite for effective immunotherapy; (2) vaccination with autological tumor cel
ls accompanied with bacille bilie de Calmette-Guerin (BCG) as the adjuvant
and with interleukin-2 as the immunostimulator effectively prevents metasta
sizing after successful surgery; (3) the vaccine must necessary contain liv
ing tumor cells adequately presenting tumor antigens; and (4) in some cases
, immunotherapy causes undesirable autoimmune complications, They can be re
gistered by corresponding inflammation control methods.