Combined surgical and immunotherapeutic treatment of patients with fourth stage colon cancer

Sixty-five patients with the fourth stage colon cancer were subjected to th e combined surgical and immunotherapy. The following conclusions are made: (1) surgical elimination of the bulk of tumor mass is a necessary prerequis ite for effective immunotherapy; (2) vaccination with autological tumor cel ls accompanied with bacille bilie de Calmette-Guerin (BCG) as the adjuvant and with interleukin-2 as the immunostimulator effectively prevents metasta sizing after successful surgery; (3) the vaccine must necessary contain liv ing tumor cells adequately presenting tumor antigens; and (4) in some cases , immunotherapy causes undesirable autoimmune complications, They can be re gistered by corresponding inflammation control methods.