'Naive' and 'memory' CD4(+) T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion
Djs. King et al., 'Naive' and 'memory' CD4(+) T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion, IMMUNOL LET, 66(1-3), 1999, pp. 199-206
The progression of 'naive' and 'memory' T-cells and the T-cell receptor V b
eta (TCR V beta) repertoire dynamics within the peripheral CD4(+) T-cell co
mpartment were studied in individuals following HIV seroconversion. Profoun
d TCR V beta repertoire perturbations were observed within the CD4(+) T-cel
l pool in treatment-naive patients regardless of their levels of viremia du
ring the first 6-8 months after seroconversion. The ratio of 'naive' to 'me
mory' CD4(+) T-cells as well as the TCR V beta repertoire dynamics did not
appear to correlate with absolute numbers of CD4(+) T-cells. (C) 1999 Elsev
ier Science B.V. All rights reserved.