'Naive' and 'memory' CD4(+) T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion

Authors
King, DJS Amjadi, P Tilling, R Kinloch-de-Loes, S Loveday, C Johnson, MA Janossy, G Tarragona, A Gotch, F Larsson-Sciard, EL
Citation
Djs. King et al., 'Naive' and 'memory' CD4(+) T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion, IMMUNOL LET, 66(1-3), 1999, pp. 199-206
Citations number
19
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY LETTERS
ISSN journal
01652478 → ACNP
Volume
66
Issue
1-3
Year of publication
1999
Pages
199 - 206
Database
ISI
SICI code
0165-2478(199903)66:1-3<199:'A'CTA>2.0.ZU;2-1
Abstract
The progression of 'naive' and 'memory' T-cells and the T-cell receptor V b eta (TCR V beta) repertoire dynamics within the peripheral CD4(+) T-cell co mpartment were studied in individuals following HIV seroconversion. Profoun d TCR V beta repertoire perturbations were observed within the CD4(+) T-cel l pool in treatment-naive patients regardless of their levels of viremia du ring the first 6-8 months after seroconversion. The ratio of 'naive' to 'me mory' CD4(+) T-cells as well as the TCR V beta repertoire dynamics did not appear to correlate with absolute numbers of CD4(+) T-cells. (C) 1999 Elsev ier Science B.V. All rights reserved.