Cancer risk in mutation carriers of DNA-mismatch-repair genes

Excessive incidence of various cancers is a challenging feature of the here ditary-non-polyposis-colorectal-cancer (HNPCC) syndrome. This study estimat ed the cancer incidences in HNPCC compared with the general population. Ind ividuals in a cohort of 1763 members of 50 genetically diagnosed families w ere categorized according to their genetic status as mutation carriers, non -carriers, or individuals at 50 or 25% risk of being a carrier. Incidences of cancers in these groups were compared with those in the Finnish populati on overall. In 360 mutation carriers, standardized incidence ratios (SIR) w ere significantly increased for colorectal [68; 95% confidence intervals (C I), 56 to 81], endometrial (62; 95% CI, 44 to 86), ovarian (13; 95% CI, 5.3 to 25), gastric (6.9; 95% CI, 3.6 to 12), biliary tract (9.1; 95% CI, 1.1 to 33), uro-epithelial (7.6; 95% CI, 2.5 to 18) and kidney (4.7; 95% CI, 1 to 14) cancers and for central-nervous-system tumours (4.5; 95% CI, 1.2 to 12). The SIR increased with increasing likelihood of being a mutation carri er. The cumulative cancer incidences were 82, 60, 13 and 12% for colorectal , endometrial, gastric and ovarian cancers respectively. For other tumours associated with increased risk, corresponding incidences were below 4%. Int erestingly, the incidence of endometrial cancer (60%) exceeded that for col orectal cancer in women (54%). The tumour spectrum associated with germline mutations of DNA-mismatch-repair genes involves 8 or more organ sites, sug gesting a need to develop methods to screen for extra-colonic cancer also. Int. J. Cancer 81:214-218, 1999. (C) 1999 Wiley-Liss, Inc.