Prognostic markers in clinically localised prostate cancer

The prognostic value of immunohistochemical staining of P53, BCL-2, p27(kip 1), PSA, AR and MIB-1 was compared with that of established prognostic vari ables (Gleason score, surgical margins, tumour volume) following radical pr ostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative margins with rising serum PSA (n=7), positive margins with stable serum PSA (n=7), positive margins with rising serum PSA (6) and patients with micrometastatic disease diagnosed in lymph nodes removed dur ing radical prostatectomy (n=8). Gleason score and tumour volume were of pr ognostic significance and immunohistochemical staining for MIB-1 and BCL-2 showed added independent prognostic significance in multivariate analysis.