Perioperative fractionated high-dose rate brachytherapy for malignant boneand soft tissue tumors

Purpose: To investigate the viability of perioperative fractionated HDR bra chytherapy for malignant bone and soft tissue tumors, analyzing the influen ce of surgical margin. Methods and Materials: From July 1992 through May 1996, 16 lesions of 14 pa tients with malignant bone and soft tissue tumors (3 liposarcomas, 3 MFHs, 2 malignant schwannomas, 2 chordomas, 1 osteosarcoma, 1 leiomyosarcoma, 1 e pithelioid sarcoma, and 1 synovial sarcoma) were treated at the Osaka Unive rsity Hospital. The patients' ages ranged from 14 to 72 years (median: 39 y ears). Treatment sites were the pelvis in 6 lesions, the upper limbs in 5, the neck in 4, and a lower limb in 1. The resection margins were classified as intracapsular in 5 lesions, marginal in 5, and wide in 6. Postoperative fractionated HDR brachytherapy was started on the 4th-13th day after surge ry (median: 6th day). The total dose was 40-50 Gy/7-10 fr/ 4-7 day (bid) at 5 or 10 mm from the source. Follow-up periods were between 19 and 46 month s (median: 30 months). Results: Local control rates were 75% at 1 year and 48% in 2 years, and ult imate local control was achieved in 8 (50%) of 16 lesions. Of the 8 uncontr olled lesions, 5 (63%) had intracapsular (macroscopically positive) resecti on margins, and all the 8 controlled lesions (100%) had marginal (microscop ically positive) or wide (negative) margins. Of the total, 3 patients died of both tumor and metastasis, 3 of metastasis alone, I of tumor alone, and 7 showed no evidence of disease. Peripheral nerve palsy was seen in one cas e after this procedure, but no infection or delayed wound healing caused by tubing or irradiation has occurred. Conclusion: Perioperative fractionated HDR brachytherapy is safe, well tole rated, and applicable to marginal or wide surgical margin cases. (C) 1999 E lsevier Science Inc.