Sl. Hale et Ra. Kloner, Myocardial hypothermia: A potential therapeutic technique for acute regional myocardial ischemia, J CARD ELEC, 10(3), 1999, pp. 405-413
Citations number
29
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Cardioprotection by Mild Hypothermia. The importance of temperature in the
development of necrosis after myocardial ischemia in the beating heart is b
ecoming apparent. Recent studies have shown that the proportion of the isch
emic risk zone that becomes necrotic is directly correlated with temperatur
e. This fact suggests the potential therapeutic benefits of reducing myocar
dial temperature after coronary artery occlusion, We have shown in a number
of experimental protocols in the rabbit model of myocardial infarction tha
t topical regional hypothermia reduces infarct size even when instituted af
ter coronary artery occlusion, The reduction in myocardial temperature requ
ired to obtain this benefit is modest (30 degrees C to 34 degrees C). Topic
al regional hypothermia allows targeted cooling of a zone of the heart, Myo
cardial cooling can also be achieved by perfusing the pericardial sac with
a chilled fluid by using a closed-circuit catheter system that does not cau
se cardiac tamponade, This technique also protects myocardium during ischem
ia, Myocardial hypothermia might be a useful technique to limit ischemic da
mage during infarction or as adjunctive therapy during minimally invasive c
ardiac surgery.