Synthesis, characterization and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 5-aryl-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrimidines

Authors
Quiroga, J Insuasty, B Hormaza, A Gamenara, D Dominguez, L Saldana, J
Citation
J. Quiroga et al., Synthesis, characterization and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 5-aryl-2-phenyl-6,7-dihydropyrazolo[1,5-a]pyrimidines, J HETERO CH, 36(1), 1999, pp. 11-13
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
36
Issue
1
Year of publication
1999
Pages
11 - 13
Database
ISI
SICI code
0022-152X(199901/02)36:1<11:SCAIVA>2.0.ZU;2-J
Abstract
Several new pyrazolo[1,5-a]pyrimidines were obtained from the reaction of 1 H-5-amino-3-phenylpyrazole (1) with beta-dimethylaminopropiophenones 2 in p yridine, The structure elucidation of 6,7-dihydropyrazolo[1,5-a]pyrimidines 3 is based on nmr measurements. These compounds showed moderate anthelmint ic in vitro activity against the Nipposirongylus brasiliensis model.