Preparation of 1,2-disubstituted-3-hydroxy-4(1H)-quinolinones and the influence of substitution on the course of cyclization

Authors
Hradil, P Hlavac, J Lemr, K
Citation
P. Hradil et al., Preparation of 1,2-disubstituted-3-hydroxy-4(1H)-quinolinones and the influence of substitution on the course of cyclization, J HETERO CH, 36(1), 1999, pp. 141-144
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
36
Issue
1
Year of publication
1999
Pages
141 - 144
Database
ISI
SICI code
0022-152X(199901/02)36:1<141:PO1ATI>2.0.ZU;2-H
Abstract
Synthesis of 1,2-disubstituted-3-hydroxy-4(1H)-quinolinones by the cyclizat ion of N-substituted phenacyl or acetonyl anthranilates is described. Two m ethods were employed for cyclization of anthranilates. Heating in polyphosp horic acid has a wide scope of applicability. The thermal cyclization in bo iling N-methylpyrrolidone is limited by steric effect.