Synthesis of certain 5-substituted thieno[2,3-b] thiophene-2-sulfonamides and thieno[2,3-b]thiophene-2-sulfonamide 6,6-dioxides

Authors
Chen, HH May, JA Lynch, VM
Citation
Hh. Chen et al., Synthesis of certain 5-substituted thieno[2,3-b] thiophene-2-sulfonamides and thieno[2,3-b]thiophene-2-sulfonamide 6,6-dioxides, J HETERO CH, 36(1), 1999, pp. 249-256
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
36
Issue
1
Year of publication
1999
Pages
249 - 256
Database
ISI
SICI code
0022-152X(199901/02)36:1<249:SOC5TT>2.0.ZU;2-D
Abstract
A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno[2,3-b]thiophene -2-sulfonamides provided the first examples of thiophene[2,3-b]thiophene-2- sulfonamide 6,6-dioxides. These cyclic vinyl sulfones readily underwent add ition to give predominately that 4,5-cis addition product.