MIG, THE MONOKINE INDUCED BY INTERFERON-GAMMA, PROMOTES TUMOR NECROSIS IN-VIVO

Mig, the monokine induced by interferon-gamma, is a CXC chemokine acti ve as a chemoattractant for activated T cells. Mig is related function ally to interferon-inducible protein 10 (IP-10), with which it shares a receptor, CXCR3, Previously, IP-10 was found to have antitumor activ ity in vivo, In the present study, murine Mig RNA was found to be expr essed at higher levels in regressing Burkitt's lymphoma tumors establi shed in nude mice compared with progressively growing tumors, Daily in oculations of purified recombinant human Mig into Burkitt's tumors gro wing subcutaneously in nude mice consistently caused tumor necrosis as sociated with extensive vascular damage. These effects were indistingu ishable from those produced by intratumor inoculations of Burkitt's tu mors with IP-10, These results support the notion that Mig, like IP-10 , has antitumor activity in vivo, This is a US government work.