The formulation of the principle of superposition in the presence of non-compliance and its applications in multiple dose pharmacokinetics

The principle of superposition is an important tool for studying multiple d ose pharmacokinetics. In this paper, the principle of superposition in the presence of noncompliance is formulated generally as a recursive formula. W ith this powerful tool, we are able to provide a simple proof under general conditions for the fundamental result that steady state AUC is equal to th e single-dose AUC for any concentration curve. In another application of th e principle of superposition, superposition, we establish the relationship between the steady slate average concentration and patient compliance index .