We describe the case of a 53-year-old man in whom pigmented bowenoid papulo
sis developed on the skin of the neck. By polymerase chain reaction with ge
neral primers for genital human papillomaviruses (HPV) and subsequent restr
iction enzyme cleavage we could demonstrate HPV I X-related DNA in two biop
sy specimens of the pigmented papules. To our knowledge, this report repres
ents the first case of HPV 18-induced extragenital bowenoid papulosis of th
e neck.