Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to the beta and gamma subunits of laminin 5

Anti-epiligrin cicatricial pemphigoid is an autoimmune subepithelial bliste ring disorder of mucous membranes and skin. By immunoblot analyses, sera of most patients with anti-epiligrin cicatricial pemphigoid have been shown t o react specifically with the alpha 3 chain of laminin 5, We describe the f irst patient with anti-epiligrin cicatricial pemphigoid in whom circulating Ige autoantibodies directed against the beta 3 and gamma 2-chains of lamin in 5 were detected. Treatment with oral prednisolone was beneficial in cont rolling the disease.