BROMINATION OF PYRIMIDINES USING BROMIDE AND MONOPEROXYSULFATE - A COMPETITION STUDY BETWEEN CYTIDINE, URIDINE AND THYMIDINE

Authors
ROSS SA BURROWS CJ
Citation
Sa. Ross et Cj. Burrows, BROMINATION OF PYRIMIDINES USING BROMIDE AND MONOPEROXYSULFATE - A COMPETITION STUDY BETWEEN CYTIDINE, URIDINE AND THYMIDINE, Tetrahedron letters, 38(16), 1997, pp. 2805-2808
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
16
Year of publication
1997
Pages
2805 - 2808
Database
ISI
SICI code
0040-4039(1997)38:16<2805:BOPUBA>2.0.ZU;2-A
Abstract
Bromination of pyrimidine nucleotides in aqueous conditions can be con veniently carried out using a mixture of potassium bromide and potassi um monoperoxysulfate (Oxone). Deoxycytidine can also be selectively br ominated in reaction mixtures containing uridine and thymidine. NMR st udies show the course of the reaction and formation of 5-bromopyrimidi ne products. (C) 1997 Elsevier Science Ltd.