Thermoanalytical studies on complexes of furosemide with beta-cyclodextrinderivatives

Solid formulas obtained between furosemide and two beta-cyclodextrin deriva tives (HP-beta-CD and RAMEB) were prepared by different methods and in vari ous ratios (1:I and 1.2). The inclusion complex formation between the drug and the beta-CDs of 1:1 ratio was evaluated by mean of thermal analysis (DS C, TG and EGD). Supplementary techniques, such as X-ray diffraction, were a lso applied to interpret the results of the thermal study of physically mix ed and kneaded products. Both studies demonstrated the formation of inclusi on complexes in all samples except the physical mix samples; formation of t rue inclusion complexes was then possible only when the components were in melted form. The complexation increased the solubility and the rate of diss olution of the drug. RAMEB was found to be a better complexing agent than H P-beta-CD; in both ratios it can be selected as a vehicle in furosemide tab let preparations.