T. Jayashree et C. Subramanyam, Antiaflatoxigenic activity of eugenol is due to inhibition of lipid peroxidation, LETT APPL M, 28(3), 1999, pp. 179-183
Eugenol inhibited aflatoxin production by Aspergillus parasiticus NRRL 2999
in a dose-dependent manner up to a concentration of 0.75 mmol l(-1) withou
t inhibiting growth. When the mould was grown for 3 d in the presence of 0.
45 mmol l(-1) eugenol (concentration inhibiting aflatoxin production by 50%
), in vivo activities of components of polysubstrate monooxygenase were dec
reased at idiophase, concomitant with decreased activities of enzymes invol
ved in free radical scavenging, lipid peroxidation and maintenance of redox
potential. These results indicate that antiaflatoxigenic actions of eugeno
l may be related to inhibition of the ternary steps of aflatoxin biosynthes
is involving lipid peroxidation and oxygenation.