Actinorhodin production by Streptomyces coelicolor A3(2) in iron-restricted media

Authors
Coisne, S Bechet, M Blondeau, R
Citation
S. Coisne et al., Actinorhodin production by Streptomyces coelicolor A3(2) in iron-restricted media, LETT APPL M, 28(3), 1999, pp. 199-202
Citations number
12
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
LETTERS IN APPLIED MICROBIOLOGY
ISSN journal
02668254 → ACNP
Volume
28
Issue
3
Year of publication
1999
Pages
199 - 202
Database
ISI
SICI code
0266-8254(199903)28:3<199:APBSCA>2.0.ZU;2-B
Abstract
Production of the polyketide antibiotic actinorhodin by Streptomyces coelic olor A3(2) was investigated using a defined medium with or without iron sup plementation. Iron limitation was found to enhance the intracellular produc tion and export of the pigmented antibiotic. The effect of iron deficiency was particularly pronounced when the bacterium was grown with nitrate inste ad of ammonium. Analysis of the excreted pigment led to the identification of the lactone form of actinorhodin, gamma-actinorhodin.