F. Zelaya et al., An evaluation of the time dependence of the anisotropy of the water diffusion tensor in acute human ischemia, MAGN RES IM, 17(3), 1999, pp. 331-348
We have performed MRI examinations to determine the water diffusion tensor
in the brain of six patients who were admitted to the hospital within 12 h
after the onset of cerebral ischemic symptoms. The examinations have been c
arried out immediately after admission, and thereafter at varying intervals
up to 90 days post admission. Maps of the trace of the diffusion tensor, t
he fractional anisotropy and the lattice index, as well as maps of cerebral
blood perfusion parameters, were generated to quantitatively assess the ch
aracter of the water diffusion tensor in the infarcted area. In patients wi
th significant perfusion deficits and substantial lesion volume changes, fo
ur of six cases, our measurements show a monotonic and significant decrease
in the diffusion anisotropy within the ischemic lesion as a function of ti
me. We propose that retrospective analysis of this quantity, in combination
with brain tissue segmentation and cerebral perfusion maps, may be used in
future studies to assess the severity of the ischemic event. (C) 1999 Else
vier Science Inc.