Effects of gender and region on proton MRS of normal human brain

Localized, in vivo H-1 magnetic resonance spectroscopy has been performed i n a number of brain regions of neuropsychiatric interest in male and female control subjects to determine if gender and region affect the measured met abolite ratios. In contrast to some previous reports, no significant differ ences mere seen in any region for any metabolite ratio between males and fe males. As expected, significant variations,vith brain region were seen for metabolite ratios for the total group of subjects. (C) 1999 Elsevier Scienc e Inc.