Citation
B. Miskowiak et al., Endogenous neurotensin exerts a tonic stimulatory action on adrenocorticalsecretion in the rabbit, MED SCI RES, 27(1), 1999, pp. 3-5
Citations number
16
Categorie Soggetti
Medical Research General Topics
Journal title
MEDICAL SCIENCE RESEARCH
ISSN journal
02698951
→ ACNP
Volume
27
Issue
1
Year of publication
1999
Pages
3 - 5
Database
ISI
SICI code
0269-8951(199901)27:1<3:ENEATS>2.0.ZU;2-N
Abstract
We have investigated the effects of the bolus intravenous administration of
neurotensin (NT) and its receptor antagonist [D-Trp(11)]-NT (NT-A) on the
function of the pituitary-adrenocortical axis in the rabbit. Neither NT nor
NT-A changed the ACTH plasma concentration with respect to control (vehicl
e-injected) animals. NT did not evoke significant changes in either aldoste
rone or corticosterone secretion, while NT-A significantly decreased hormon
al production as compared to control rabbits. Taken together, our results s
uggest that endogenous NT exerts a maximal tonic stimulatory action on adre
nal secretory activity in the rabbit, which is independent of any effect on
the pituitary ACTH release. Med Sci Res 27:3-5 (C) 1999 Lippincott William
s & Wilkins.