Putrescine GABA profile in human breast, rectal, ovarian, cervical and endometrial carcinoma

In previous investigations, we showed the existence of a gamma-amino butyri c acid (GABA) shunt pathway in human brain tumour tissue and in experimenta l carcinoma induced by dimethylbenzanthracene (DMBA) in brain tissue of mic e. This pathway shows putrescine carbon incorporation to GABA by diamine ox idase (DAO) without the involvement of glutamic acid. There is very little information regarding the existence of such a pathway in nonneural tissues. However, there is some evidence regarding the occurrence of GABA in non-ne ural tissues. Since putrescine, the diamine precursor of polyamines, plays an essential role in cellular growth, we have studied the putrescine GABA p rofile in human breast, rectal, ovarian, cervical and endometrial carcinoma tous tissues in respect to their adjacent controls. In this study, the conc entrations of putrescine, DAO and GABA were significantly elevated in human breast, rectal, ovarian, cervical and endometrial carcinomatous tissues in comparison to their adjacent control tissues. Med Sci Res 27:49-51 (C) 199 9 Lippincott Williams & Wilkins.